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MOTS-C
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Research Use Only
Research Use Only - All products are intended solely for laboratory research and are not for human or animal consumption. By purchasing, the buyer agrees to use these products in compliance with all applicable laws.
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MOTS-C
Overview
MOTS-c is a mitochondrial-derived peptide encoded within the 12S rRNA gene. This 16-amino acid peptide has been extensively studied for its role in metabolic homeostasis. Research indicates its involvement in regulating insulin sensitivity and influencing exercise adaptation. Its unique origin and metabolic functions make it a subject of significant scientific interest.
History
The discovery of MOTS-c in 2015 marked a significant advancement in understanding mitochondrial signaling. Initial investigations focused on its ability to regulate metabolism, particularly glucose utilization in skeletal muscle. Early studies highlighted its potential to influence insulin sensitivity and protect against dietinduced metabolic dysfunction. This foundational work paved the way for broader research into its systemic effects.
MOTS-C
Structure

Molecular Formula:
C101H152N28O22S2
Molecular Weight:
2174.6 g/mol
PubChem ID:
176489569
Research Findings
MOTS-c has been investigated across various biological systems, revealing its multifaceted influence on cellular and systemic metabolism. Studies have explored its impact on glucose regulation, energy expenditure, and cellular resilience.
Key Areas of Research:
Metabolic: Homeostasis, glucose, lipids
Insulin: Sensitivity, resistance, signaling
Exercise: Adaptation, performance, recovery
Cellular: Mitochondria, energy, protection
These findings collectively suggest that MOTS-c plays a crucial role in maintaining metabolic balance and responding to physiological stressors. Its activity in diverse pathways provides a strong basis for further exploration into its therapeutic potential.
References
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